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Abstract #2388

Anatomical & Metabolic Changes in the Visual Cortex of Streptozotocin-Treated Type 1 Diabetic Rats

Mingming Huang1, Lifeng Gao1, Guanjun Zhu1, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of

Type 1 diabetes was induced in rats by a single-dose intraperitoneal injection of streptozotocin (STZ). High resolution anatomical images were acquired with a RARE sequence and in vivo 1H spectra of the visual cortex by a PRESS sequence at 12 weeks after induction. The STZ-treated rats showed significantly increased myo-inositol/creatine ratio, and significantly reduced NAA/creatine ratio and thickness in the visual cortex. These results indicated that chronic diabetic complications involves anatomical and metabolic changes in the visual cortex.