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Abstract #2392

Global Cerebral Metabolic Oxygen Consumption Rate & Cerebral Blood Flow Can Be Measured Reliably During Oxygen Inhalation

Naranjargal Dashdorj1, Katherine Corrie2, Antonio Napolitano1, Samuel Wharton3, Esben Thade Petersen4, Ravi Mahajan2, Dorothee P. Auer1

1Academic Radiology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Division of Anaesthesia, University of Nottingham, Nottingham, United Kingdom; 3School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom; 4National Neuroscience Institute, Singapore

Global cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow are important physiological indices of brain function and metabolism. Noninvasive measurements of these markers would be valuable in clinical neuroscience. In recent years, it has been shown that CMRO2 and CBF can be quantified using MRI techniques. Specifically, susceptometry-based oxymetry has been shown to be a quick way to quantify global cerebral metabolic changes. However, the robustness and reliability of this technique has not been tested during various physiological challenges. Quantifications of global cerebral metabolic changes during anaesthesia and different pathological conditions are of interest in neuroscience and clinical practice. This study investigated the feasibility and reliability of CMRO2 and CBF quantifications during 40% oxygen inhalation