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Abstract #2398

Effect of Manganese Chloride on the Neurochemical Profile of the Rat Hypothalamus

Nathalie Just1,2, Cristina Cudalbu1, Hongxia Lei1,2, Rolf Gruetter1,3

1LIFMET, CIBM/EPFL, Lausanne, Switzerland; 2Department of Radiology, UNIL, Lausanne, Switzerland; 3Department of Radiology, UNIL&HUG, Lausanne & Geneve, Switzerland

The hypothalamus is responsible for metabolic processes of the Autonomic Nervous System. In this context, the hypothalamus demonstrated a crucial role in the regulation of food intake and energy balance. Manganese-Enhanced MRI techniques applied to the rat hypothalamus revealed that the paraventricular nuclei and the lateral hypothalamus show specific enhancement patterns following food challenges. Such studies appear to be of great interest for a better understanding of the neuronal pathways of the hypothalamus. Here, we propose to investigate the influence of manganese on the hypothalamic neurochemical profile of normal and dehydration-induced anorexic rats using proton MRS at 14.1T.