Meeting Banner
Abstract #2404

Topical Administration of Mn2+ for MEMRI May Not Enter Vitreous Space to Reach Retina

Bruce W. Campbell1, Eric Won, Hsiao-Fang Liang2, Shu-Wei Sun3

1Clinical Laboratory Science, School of Allied Health, Loma Linda University, Loma Linda, CA, United States; 2Biophysics & Bioengineering, Loma Linda University; 3Biophysics & Bioengineering, Loma Linda University, Loma Linda, CA, United States

High resolution T1-Weighted Imaging of the eye was repeatedly acquired every 30 minutes in the initial 4 hours after MnCl2 (1 M) loading. Noticeable increments of signal were found in the retina and lens border. In 240 minutes after the MnCl2 induction, the retina signal increased 70% (p < 0.05), and the lens border signal increased 80% (p < 0.05). Interestingly, no significant change occurred in the vitreous space. Topical administration of Mn2+ for MEMRI may not enter vitreous space to reach retina.