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Abstract #2407

Comparing Topical Administration & Intravitreal Injection of Mn2+ for MEMRI on Mouse Visual Pathway

Bruce W. Campbell1, Eric Won, Chantal Lunderville, Hsiao-Fang Liang2, Shu-Wei Sun3,4

1Clinical Laboratory Science, School of Allied Health, Loma Linda University, Loma Linda, CA, United States; 2Biophysics & Bioengineering, Loma Linda University; 3Biophysics & Bioengineering, Loma Linda University, Loma Linda, CA, United States; 4Radiation Medicine, Loma Linda University

Topical administration (0.5M, 0.75M, 1.0M, and 1.5M MnCl2) and intravitreal injection (1.0M MnCl2) were evaluated and compared for MEMRI on mouse visual system. Our data showed that the signal enhancement was dependent on the concentration of applied MnCl2. Comparing topical administration and intravitreal injection, 1.0M topical administration resulted in significant enhancements in retina, optic nerves, and superior colliculus, which were similar to the results of intravitreal injection.