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Abstract #2416

Perfusion Weighted Imaging Directed Proton MR Spectroscopy: A New Approach to Identify Oligodendroglial Genotypes

Sanjeev Chawla1, Yu Zhang2, Jaroslaw Krejza1, Sumei Wang1, Gurpreet Kapoor3, Sangeeta Chaudhary1, Arastoo Vossough1, Donald O' Rourke3, Elias R. Melhem1, Harish Poptani1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Radiology, University of Pennsylvania,, Philadelphia, PA, United States; 3Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States

To identify oligodendroglial genotypes, 1H-MRS voxels guided by perfusion weighted imaging were analyzed from 34 patients [1p/19q deletion (Group I, n=19), and intact alleles (Group II, n=15)]. 1H-MRS grid was overlaid on CBV maps. CBV values were obtained by drawing ROIs from the tumor and were normalized to contralateral white-matter to obtain relative rCBV values. 1H- MRS indices were computed from maximum rCBV regions and logistic regression analyses was performed. Using a combination of maximum rCBV and Cho/Cr from the maximum rCBV ROI resulted in a sensitivity of 73% and specificity of 84% in distinguishing the two groups of oligodendrogliomas.