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Abstract #2426

Demonstration of the Relationship between Oxygen Delivery & Contrast Agent Delivery in Human Glioma using Combined OEMRI & DCE-MRI

Katherine Frances Holliday1,2, Gerard Thompson1,2, Samantha Jane Mills1,2, Giovanni Buonaccorsi1,2, Alan Jackson1,2, Josephine H. Naish1,2, Geoffrey J. M. Parker1,2

1Imaging Sciences, The University of Manchester, Manchester, United Kingdom; 2University of Manchester Biomedical Imaging Institute, Manchester, United Kingdom

Hypoxia has been linked to tumour progression and metastasis and is also known to affect sensitivity to treatment. Oxygen-enhanced MRI is a proposed method to investigate oxygen delivery and consumption in tumour tissue non-invasively that is based on observing changes in R1 during the breathing of 100% oxygen. In this study, patients with glioma underwent both OEMRI and DCE-MRI. Oxygen-enhanced R1 change was calculated on a voxel-wise basis, and regions with significant changes in both directions were identified. Correlations were found between these R1 changes and contrast agent uptake during DCE-MRI, suggesting identification of both poorly-perfused hypoxic regions and well-perfused, well-oxygenated regions.