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Abstract #2431

Water Chemical Shift Differences Detected in Childhood Brain Tumours May Indicate Temperature Variations & Fast Exchange Effects

Nigel Paul Davies1, Maryam Kalantari Saghafi2, Martin Wilson3, Yu Sun3, Theodoros N. Arvanitis4, Andrew C. Peet3

1Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 2School of Physics & Astronomy, University of Birmingham, Birmingham, United Kingdom; 3Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; 4Department of Electrical, Electronic, & Computer Engineering, University of Birmingham, Birmingham, United Kingdom

Temperature may be a useful supplementary biomarker for the clinical management of brain tumours. In-vivo 1H MRS can provide absolute local temperature measurements through the empirical linear relationship between temperature and water chemical shift. However, fast chemical and magnetization exchange effects also contribute to water chemical shift. This study investigates water chemical shift differences due to temperature and fast exchange effects in two types of childhood brain tumours using short-TE and long-TE 1H MRS. Significant differences in water chemical shift between tumour types and TE are found, suggesting that fast exchange effects may contribute significantly to observed apparent temperature differences.