Abstract #2433

Assessment of Tumor Perfusion by DSC MRI During Radiation Therapy in Children with Diffuse Intrinsic Pontine Glioma

Adam M. Winchell^1,2, Mehmet Kocak³, Hoang-Vu Tran¹, Ruitian Song¹, Ralf B. Loeffler¹, Alberto Broniscer⁴, Claudia M. Hillenbrand¹

¹Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States; ²Biomedical Engineering , University of Memphis, Memphis, TN, United States; ³Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States; ⁴Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

Dynamic susceptibility contrast (DSC) perfusion imaging was performed to investigate a preliminary understanding of vascular proliferation of the tumor during RT. The objective of this study was to study the evolution of perfusion using DSC during treatment of DIPG to provide markers of disease response and progression.