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Abstract #2445

Volume Shrinkage, Perfusion & Diffusion Alterations of Irradiated Parotid Glands

Cheng-Chieh Cheng1, Chun-Jung Juan2, Hsiao-Wen Chung1, Yee-Min Jen3, Hing-Chiu Chang1,4, Su-Chin Chiu1, Cheng-Yu Chen2, Chun-Jen Hsueh2, Yaoh-Shiang Lin5, Guo-Shu Huang2

1Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; 3Department of Radiation Oncology, Tri-Service General Hospital, Taipei, Taiwan; 4Applied Science Laboratory, GE Healthcare, Taipei, Taiwan; 5Department of Otorhinolaryngology-Head & Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan

Human parotid glands are highly radio-sensitive and prone to radiation injury. In this study we monitored the volume changes of the irradiated parotid glands and the parotid gland perfusion alteration. Different behaviors of the contrast agent wash-in slope were found between the mildly and severely shrank parotid glands. Whether this perfusion characteristic may help disease diagnosis as well as treatment outcome prediction is of clinical interest and deserves further investigation.