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Abstract #2457

Evaluation of Pretreatment & Early Response DCE MRI in Head & Neck Cancer: Prediction of Short-Term Outcome

Jacobus F. A. Jansen1, Yonggang Lu2, Hilda E. Stambuk2, Nancy Y. Lee2, Jason A. Koutcher2, Amita Shukla-Dave2

1Maastricht University Medical Center, Maastricht, Netherlands; 2MSKCC, NY, United States

An advantage of the noninvasive MRI technique is that subjects can be imagined multiple times before, during and, after treatment. In this study we assess the value of DCE-MRI derived perfusion/permeability biomarkers in predicting the short-term response to therapy in patients with head and neck squamous cell carcinoma (HNSCC) with neck nodal metastases. Sixteen patients underwent a DCE-MRI protocol before, and 10-14 days into the chemoradiation treatment. Pretreatment and early response DCE-MRI parameters were compared, and their efficacy in predicting short-term response to treatment was tested using logistic regression analysis. Pretreatment ve was a significant predictor of response. However, early response DCE marginally improves prediction of short-term response in head and neck cancer.