Abstract #2484

White Matter Biomarker from DTI for Children with Hereditary Spastic Paraplegia (HSP)

Hao Huang¹, Tien Nguyen², Linsley Smith³, Nancy Clegg³, Mauricio Delgado³

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; ²Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Arlington, TX, United States; ³Department of Neurology, Texas Scottish Rite Hospital, Dallas, TX, United States

DT-MRI is sensitive to subtle white matter structural changes which play essential roles in motor dysfunction of children with Hereditary Spastic Paraplegia (HSP). The Gross Motor Function Classification System (GMFCS) can be used to quantify severity of this disease related to motor outcome. Few studies have been conducted to survey the entire white matte to find the most sensitive white matter region which can be used for early diagnosis. Our goal is to find an effective white matter biomarker most sensitive to the severity of motor impairment of HSP for early diagnosis.