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Abstract #2507

DTI Evaluation of White Matter Integrity in Long Term Survivors of Pediatric Low Grade Gliomas

Fang Liu1, Frank Wang1, Uri Tabori2, Eric Bouffet2, Katrin Scheinemann3, Donald J. Mabbott1

1Neurosciences & Mental Health, the Hospital for Sick Children, Toronto, ON, Canada; 2Haematology/Oncology, the Hospital for Sick Children, Toronto, ON, Canada; 3Pediatrics, McMaster University, Hamilton, ON, Canada

White matter integrity following treatment for PLGG has not been examined. We investigated the differences in white matter integrity between the long-term PLGG survivors and healthy controls and specifically DTI measures of brain white matter integrity between these groups. FA was significantly lower in PLGG patients versus healthy control children in multiple areas, including bilateral occipital WM regions, corpus callosum splenium, and the brain stem. These findings provide evidence for significant white matter compromise in patients diagnosed with and treated for PLGG.