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Abstract #2530

Glutamate Correlations between the Anterior Cingulate & Cerebellar Vermis

Kevin Wayne Waddell1, Subechhya Pradhan2, Malcolm Avison1, John Gore3

1Radiology, Vanderbilt, Nashville, TN, United States; 2Physics, Vanderbilt University, Nashville, TN, United States; 3Radiology, Vanderbilt University, Nashville, TN, United States

Correlation networks among brain metabolites in the anterior cingulate (AC) and cerebellar vermis (CV) were measured with J-difference MRS. Glutamate varied linearly (r =0.61, p = 0.01) between the AC and the CV and additional inter-regional correlations were absent. Within both regions, correlations were observed between metabolites which were weakly significant when correcting for multiple comparisons (NAA and Glu; AC: r = 0.66, p = 0.01; CV: r = 0.64, p = 0.01). Correlations between and within these regions are potentially interesting and may enable further differentiation among disorders that involve the AC and CV acting in concert.