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Abstract #2536

Effect of Psychostimulants on Basal Ganglia Structures in Young ADHD Children

Laura Cyckowski1, Carolyn McIlree2, Brian Avants3, Philip Cook3, Melissa Narain4, Ruth Milanaik5, Li Kan5, Jeffrey Newcorn6, Josephine Elia, James Gee3, Andrew Adesman7, Manzar Ashtari

1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States; 2University of Vermont College of Medicine, Burlington, VT, United States; 3University of Pennsylvania, Philadelphia, PA, United States; 4Zucker Hillside Hospital, North Shore LIJ Health Systems, Glen Oaks, NY, United States; 5Schneider Children's Hospital, New Hyde Park, NY, United States; 6Mount Sinai School of Medicine, New York, NY, United States; 7Schneider Children's Hospital, New Hyde Park, PA, United States

Basal ganglia volumes in medicated (n=11) and med-nave (n=20) ADHD children (7-11 years) and matched healthy controls (n=25) were analyzed. Images were obtained on a GE 1.5T magnet and analyzed with ANTS software. Partial correlations (controlling for brain volume) of basal ganglia volumes with Conners' hyperactivity scores showed a correlation for the right caudate in med-nave subjects. Correlation analyses between duration of medication exposure in the medicated group and basal ganglia volumes revealed a negative partial correlation for the left (r=-0.61; p=0.032) and the right caudate (r=-0.51; p=0.06) with medication duration, with a longer duration corresponding to a smaller caudate.