Louise Emsell1,2, Camilla Langan1, Helen Casey1, Sarah Hehir1, Rory Nannery1, Wil Van Der Putten1, Peter McCarthy1, Colm McDonald1, Dara M. Cannon1
1NUI Galway, Galway, Co.
This study sought to identify trait related structural MRI abnormalities in the hippocampus in 60 prospectively confirmed euthymic bipolar I disorder patients compared to 60 individually age and gender matched controls. Hippocampi were traced manually using predefined anatomical boundaries. A repeated measures ANCOVA analysis including diagnosis, gender and hemisphere with age and total intracranial volume as covariates demonstrated subtle reductions in the hippocampal volume of patients bilaterally (p=0.046). There were no other significant findings including correlations within patients related to illness duration or medication status.