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Abstract #2539

Hippocampal Structural MRI Abnormalities in Euthymic Bipolar I Disorder

Louise Emsell1,2, Camilla Langan1, Helen Casey1, Sarah Hehir1, Rory Nannery1, Wil Van Der Putten1, Peter McCarthy1, Colm McDonald1, Dara M. Cannon1

1NUI Galway, Galway, Co. Galway, Ireland; 2Developmental & Functional Brain Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia

This study sought to identify trait related structural MRI abnormalities in the hippocampus in 60 prospectively confirmed euthymic bipolar I disorder patients compared to 60 individually age and gender matched controls. Hippocampi were traced manually using predefined anatomical boundaries. A repeated measures ANCOVA analysis including diagnosis, gender and hemisphere with age and total intracranial volume as covariates demonstrated subtle reductions in the hippocampal volume of patients bilaterally (p=0.046). There were no other significant findings including correlations within patients related to illness duration or medication status.