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Abstract #2560

Semi-Automatic Segmentation of Bony Lesions from Diffusion Weighted MRI to Assess Disease Burden & Quantify Response using Markov Random Fields

Matthew David Blackledge1, Dow-Mu Koh1, Anwar R.. Padhani2, James J. Stirling2, N. Jane Taylor2, David J. Collins1, Martin O. Leach1

1CR-UK & EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, London, United Kingdom

A recent technique (DWIBS) employs fat suppressed whole-body diffusion weighted images for visual localization of metastases throughout the body. We provide a semi-automatic method for defining suspect regions in DWIBS data sets using Markov random field models and assess the utility of this technique for providing whole body tumour volume estimates.