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Abstract #2568

3D Variography of Human White Matter & the Influence of Age

Fabian Keil1, Ana Maria Oros-Peusquens1, Nadim Jon Shah1,2

1Institute of Neuroscience & Medicine - 4, Forschungzentrum Juelich, Juelich, Germany; 2Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

Healthy human white matter (WM) shows hardly any contrast on MR images. One exception to this are frequently occurring hyperintensities (WMH) in T2 weighted acquisitions of elderly patients. In order to investigate structural changes in the WM before the manifestation as WMH, we propose a method for the statistical analysis of MRI data based on approaches known from geosciences. This method allows for the quantification of tissue homogeneity on various length scales. The results from 15 female volunteers showed significant correlations with age.