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Abstract #2571

Correlation of Magnetic Susceptibility with Structural Characteristics in White Matter Regions of the Central Nervous System

Cynthia Wisnieff1, Tian Liu1, Krishna Surapaneni, MD, MPH2, Craig I. Horenstein, MD2, Yi Wang1,3

1Biomedical Engineering, Cornell University, Ithaca, NY, United States; 2Department of Radiology, Columbia University, New York, NY, United States; 3Radiology, Weill Cornell Medical College, New York , NY, United States

Quantitative susceptibility mapping (QSM) of the brain is quantitative assessment of tissue magnetic properties and recent observations have shown that the observed susceptibility in the brain may have an additional structural orientation dependency. This is especially important in the white matter of the central nervous system(CNS) where diffusion tensor imaging(DTI) has shown highly ordered structures with varying orientations to the B0 magnetic field. This study compares fiber orientations derived from DTI in white matter regions and correlates these structural measures with QSM to show significant correlations between the fiber orientation and the QSM value of white matter tracts. Further studies into the composition and orientation are required to better understand the observed correlation.