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Abstract #2580

ICA Analysis of Brachial Plexus Injury in an Animal Model Reveals Rapid Brain Plasticity in 9.4 T

Rupeng Li1, J. B. Stephenson, IV2, Christopher Pawela, Ji-Geng Yan2, Andrew Nencka, Anthony G. Hudetz3, Hani Matloub2, James .S Hyde1

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Plastic Surgery, Medical College of Wisconsin; 3Anesthesiology, Medical College of Wisconsin

We demonstrated that ICA can be used to show the somatosensory network in rat brain. This network is symmetrical in both hemispheres across the S1 area in healthy animals. Following brachial plexus avulsion injury, this network was disrupted. The somatosensory network on the injuried side switched from a synergic functional network to an anti-correlated network, which, we believe, is related to inhibitory neuronal activity.