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Abstract #2585

Surface Morphometry of Subcortical Structures in Premature Neonates

Yalin Wang1, Ashok Panigrahy2,3, Rafael Ceschin2, Songling Liu1, Paul M. Thompson4, Natasha Lepor3

1Computer Science & Engineering, Arizona State University, Tempe, AZ, United States; 2Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States; 3Radiology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 4Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, United States

Changes in surface morphometry of the corpus callosum and lateral ventricles are likely sensitive indicators of diffuse white matter injury and of the interrelated subcortical grey matter injury in preterm neonate. Using brain structural magnetic resonance (MR) images, we propose a novel pipeline for regional group comparisons of the surface anatomy of subcortical structures in neonates. We study a total of 7 brain subcortical structures: the corpus collosum, lateral ventricle, thalamus, hippocampus, caudate nucleus, putamen and the 3rd ventricle. Our analysis will be applied to compare MR data of premature neonates to those of healthy term born neonatal controls.