Meeting Banner
Abstract #2589

Atrophy in Rats Induced with Mild TBI and Hemorrhagic Shock: A TBM-Based Analysis

Priya Goel1, Sushmita Datta1, Kurt H. Bockhorst1, Jovany C. Navarro2, Claudia S. Robertson2, Ponnada A. Narayana1

1Diagnostic & Interventional Imaging, Medical School, the University of Texas Health Science Center at Houston, Houston, TX, United States; 2Neurosurgery, Baylor College of Medicine, Houston, TX, United States

In this study, we investigated the regional volume changes in brain caused by mild traumatic brain injury with hemorrhagic shock in rat models using tensor-based morphometry (TBM) that has methodological advantages over the commonly used voxel-based morphometric (VBM) techniques. Our analysis resulted in the detection of atrophy at the site of injury and some deep gray matter structures such as amygdala and suprachiasmatic nucleus which might perhaps explain the various post-traumatic disorders that the mTBI victims suffer.