Abstract #2592

In Vivo MR Quantification of Liver Fat Content in Obese Mice: Comparison of Dual-Echo Dixon Imaging, Chemical Shift Selective Imaging & Hydrogen MR Spectroscopy

Shenghong Ju¹, Xin-Gui Peng¹

¹Department of Radiology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China, People's Republic of

T1WI can be used to measure liver volume and observe fat distribution; IP-OP method gives a FC that is significantly lower than the actual value, especially in higher fat concentrations; CSI and 1H MRS are accurate in quantifying fat in both phantoms and liver in vivo. Given their excellent correlation and concordance with LL analysis, CSI and MRS may replace liver fat histological and chemical analysis in longitudinal studies.