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Abstract #2594

Computation of Structure Model Index in the Spatial Resolution Regime of In Vivo Trabecular Bone MRI

Shing Chun Benny Lam1, Jeremy F. Magland1, Scott N. Hwang2, Felix W. Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Radiology, Emory University, Atlanta, GA, United States

The structure model index (SMI) is a metric characterizing the structure type (plate versus rod) of a trabecular bone network. However, application of SMI to in vivo MRI has been limited by spatial resolution. Here, we explored two up-sampling methods, sinc-interpolation and subvoxel processing, to enable computation of SMI from in vivo MRI. Comparison with values derived from CTimages (regarded as ground truth) showed SMI values obtained from subvoxel processed images to be closer to ground truth than those derived from sinc-interpolated images in terms of correlation coefficients and root mean square differences. Finally, subvoxel processed images were less sensitive to variations in binarization threshold.