Abstract #2632

Influence of Fat-Sat & Non-Fat-Sat Imaging Sequences, Spatial Resolution, & Breast Morphological Types on Density Measurements

Daniel Han-en Chang^1,2, Jeon-Hor Chen^1,3, Muqing Lin^1,2, Shadfar Bahri^1,2, Hon J. Yu^1,2, Rita S. Mehta⁴, Ke Nie^1,2, David J. B. Hsiang⁵, Orhan Nalcioglu^1,2, Min-Ying Lydia Su^1,2

¹Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; ²Department of Radiological Sciences, University of California, Irvine, CA, United States; ³Department of Radiology, China Medical University Hospital, Taichung, Taiwan; ⁴Department of Medicine, University of California, Irvine, CA, United States; ⁵Department of Surgery, University of California, Irvine, CA, United States

The differences in breast density parameters and the intra-rater variability analyzed on fat-sat vs. non-fat-sat imaging sequences in women presenting central and mixed breast morphological types were investigated. The measured breast volume on fat-sat and non-fat-sat sequences was almost identical; but there was a small (<5%) difference in fibroglandular volume and percent density, higher on fat-sat sequence. Intra-operator variability was within 4% for both sequences and different breast morphological types. Analysis based on images at original and reduced spatial resolution showed a small yet significant difference, indicating the potential influence of partial volume effect on density measurements.