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Abstract #2636

Evaluation of Spatial Changes of Fibroglandular Tissue in the Breast between Two Scans using Non-Rigid Registration Method

Muqing Lin1, Jeon-Hor Chen1,2, Shadfar Bahri1, Siwa Chan3, Tzu-Ching Shih4, Ke Nie1, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Tu & Yuen Center for Functional Onco-Imaging & Department of Radiological Sciences, University of California, Irvine, CA, United States; 2Department of Radiology, China Medical University, Taichung, Taiwan; 3Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; 4Department of Biomedical Imaging & Radiological Science, China Medical University, Taichung, Taiwan

The purpose is to evaluate changes of fibroglandular tissue in two breast MRI scans taken at different times, to provide information about spatial change pattern of breast density with virtual display. The registration method is based on rigid alignment followed by non-rigid Demons algorithm. The methods are applied to cases that show different degrees of changes. The tool reveals breast density atrophy in patients receiving chemotherapy, and shows very little change between two scans of normal volunteers with 1-week apart. This co-registration method may provide a very useful tool for comparing screening MRIs taken yearly for detection of early abnormality.