Meeting Banner
Abstract #2681

Motion Degradation in 3D MRI of Trabecular Bone: Relevance to Quantitative Analysis of Clinical Data

Yusuf A. Bhagat1, Chamith S. Rajapakse1, Jeremy F. Magland1, Michael J. Wald1, Hee K . Song1, Mary B. Leonard2, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, University of Pennsylvania, Philadelphia, PA, United States; 2Nephrology, the Children's Hospital of Philadelphia, United States

Subtle subject movement during high-resolution MR scanning of trabecular bone (TB) causes blurring rendering the data unreliable for quantitative analysis. Images that were visually free of motion artifacts from two groups of 10 healthy individuals each differing in age were selected. We then applied retrospectively derived translational motion trajectories as phase shift to the k-space data of these 20 subjects. Motion induction affected all TB structural parameters. The significant difference in structural parameter group means of the motion-free images was lost upon motion degradation. The results underscore the importance of subject movement and its correction for TB structure analysis.