Julien Y. Bouvier1,2, Irne Tropre,3, Marjorie Villien1,4, Sylvie Grand1,5, Assia Jaillard3,5, Omer Eker5, Olivier Detante1,5, David Chechin2, Jean-Franois Le Bas5, Alexandre Krainik1,5, Emmanuel L. Barbier1,4
1Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France; 2Philips Healthcare, Suresnes, France; 3IFR1, Grenoble, France; 4U836, INSERM, Grenoble, France; 5CHU, Grenoble, France
A simple MR approach for local oxygen saturation (lSO2) assessment in human brain at 3T is evaluated. It combines separate estimates of T2, T2*, Blood Volume fraction (BVf) and B0 inhomogeneities. lSO2, BVf, T2 and T2* maps of four patients are presented. Mean lSO2 values in gray matter, white matter or both were 575%, 343%, and 454% respectively. This study shows that cerebral lSO2 may be measured with good spatial resolution in a short MR exam using three MR sequences. Further studies are required to validate this promising approach in human and improve the estimates obtained in white matter.