Ana Maria Oros-Peusquens1, Fabian Keil1, Vincent Gras1, Zaheer Abbas1, Daniel Brenner1, Miriam Rabea Kubach1, Klaus Hans Mannfred Mllenhoff1, Nadim Jon Shah1,2
1Institute of Neuroscience & Medicine - 4, Forschungszentrum Juelich, Juelich, Germany; 2Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany
A new 3D method for water content and relaxation time mapping in which the M0 and T1 are determined from a two-point fit to measured data sets is presented. The method is based on 3D multiple-echo gradient echo acquisitions and thus also allows for accurate determination of T2*. The new method is applied at 3T and compared to a gold standard 2D method with very long TR. Results from phantoms and 5 healthy subjects are presented. The accuracy of the 3D method is better than 5%.