Meeting Banner
Abstract #2757

Spatially Resolved Two-Dimensional T1-T2 Relaxometry in the Human Brain using Inversion-Recovery Spin-Echo Measurements & NNLS

Valentin Gereon Kemper1, Ana-Maria Oros-Peusquens1, Nadim Jon Shah1,2

1Institute of Neuroscience & Medicine, Research Centre Juelich, Juelich, 52425, Germany; 2Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, 52074, Germany

Spatially resolved and correlated T1-T2 distribution spectra were obtained pixelwise in a human post mortem brain slice using multiple inversion recovery spin echo scans and 2D nonnegative least squares for data analysis. This way multiple T1 compartments can be associated with their respective T2 values. Resolution was 0.75x0.75x2mm3. The obtained spectra show characteristic distributions for different types of tissue yielding sub-pixel scaled information. The width of the white matter spectra is much wider in both, T1 and T2, supporting the assumption of multiple water compartments shown. Short and long component maps were obtained using both T1 and T2 distributions and their combination.