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Abstract #2767

Chemical Exchange Saturation Transfer Effect from Phospho-Creatine (PCr) & Adenosine-Tri-Phosphate (ATP)

Mohammad Haris1, Kejia Cai1, Anup Singh1, Victor Babu Kc1, Hari Hariharan1, Ravinder Reddy1

1CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, United States

In the current study, we define the chemical exchange saturation transfer (CEST) effect from phospho-creatine (PCr) and adenosine-tri-phosphate (ATP). PCr showed CEST effect at ~2.5ppm while ATP at ~2.0ppm. CEST imaging at different concentration PCr and ATP solutions was performed and mapped. We are in process of implementing the current technique to investigate mapping of PCr and Cr in-vivo on human calf muscles both at 3T and 7T and monitor exercise related changes in these metabolites.