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Abstract #2780

Optimized CEST Imaging of Intermediate to Fast Exchanging Agents in In-Vivo Situations

Anup Singh1, Hari Hariharan1, Kejia Cai1, Mohammad Haris Haris1, Ravinder Reddy1

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

In this study, optimization of saturation pulse amplitude and duration for in-vivo CEST imaging of intermediate to fast exchanging molecules is demonstrated using numerical simulations of Bloch-McConnell equations. High B1 amplitude and short duration of saturation pulse provides optimum CEST contrast with minimized contamination from slow exchanging agents and reduced SAR.