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Abstract #2930

Assessment of Hepatic Perfusion with Diffusion Weighted & Dynamic Contrast Enhanced 1H MRI in CCl4 Treated Rat Liver

Andriy Babsky1, Beena George1, George Sandusky2, Navin Bansal1

1Radiology & Imaging Sciences, Indiana University, Indianapolis, IN, United States; 2Pathology & Laboratory Medicine, Indiana University, Indianapolis, IN, United States

Use of diffusion-weighted (DW) and dynamic contrast enhanced (DCE) 1H MRI for the assessment of hepatic perfusion and diffusion parameters were evaluated in a CCl4-induced rat liver injury model. CCl4-induced liver injury caused decreases in both fast and slow apparent diffusion coefficient of water measured by DW MRI, as well as a decrease in contrast agent uptake measured by DCE MRI. DW 1H MRI should prove useful in assessment of liver damage in diffuse liver diseases without the need for a contrast agent.