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Abstract #2934

Comparison of Liver Stiffness with MRE & Fibrosis Quantification with Fibro-C Index in Chronic Hepatitis B Patients.

Sudhakar Kundapur Venkatesh1, Dean Tai2, Aileen Wee3, Shuoyu Xu4, Hanry Yu5

1Diagnostic Imaging, National University Health System, Singapore, Singapore; 2Institute of Bioengineering & Nanotechnology, Singapore, Singapore; 3Pathology, National University Health System, Singapore, Singapore; 4Singapore-MIT Alliance, Singapore, Singapore; 5Physiology, National University Health System, Singapore, Singapore

MRE has been shown to be accurate for diagnosis of liver fibrosis. In this study we compared the liver stiffness secondary to liver fibrosis determined by MRE with raw quantification of the amount of collagen in a biopsy sample by Fibro-C index technique. Study results show MRE derived stiffness of liver correlates well with fibrous content of liver biopsy. The different grades of liver fibrosis were better differentiated with MRE than by raw quantification of collagen, therefore MRE may be suitable alternative for non-invasive assessment of liver fibrosis burden in chronic hepatitis B patients and in their follow up.