1Radiology, NorthShore University HealthSystem, Evanston, IL, United States; 2Nephrology, NorthShore University HealthSystem, Evanston, IL, United States
Conventional blood markers are not sufficient to assess the severity of chronic kidney disease (CKD) and the risk for progression. It is highly desirable to develop new non-invasive markers that could reliably monitor the progression of disease over time. Renal fibrosis is considered as a hallmark of CKD and hypoxia is known to trigger fibrogenesis. We performed a preliminary cross-sectional study to compare BOLD MRI measurements in a group of CKD patients against healthy controls. We have observed a trend of increased hypoxia in CKD and a reduced response to furosemide in the medulla.