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Abstract #2959

Assessment of Renal Function by ASL in Wilms Tumor Survivors

Ruitian Song1, Ralf B. Loeffler1, Mary Beth McCarville1, Sheri L. Spunt2, Claudia Maria Hillenbrand1

1Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, United States; 2Oncology, St Jude Children's Research Hospital, Memphis, TN, United States

Renal blood flow (RBF) rates and glomerular filtration rate (GFR) were measured using arterial spin labeling (ASL) and creatinine clearance (CrCl) tests, respectively, in 23 long-term survivors of unilatral Wilms tumor. Correlations between GFR and RBF were examined in radiotherapy, non-radiotherapy groups. r= 0.78 was found in all the patients. The correlation in the non-radiotherapy group (r=0.89) was better than that in the radiotherapy group (r=0.68). The radiation damage may enhance the probability for unstable renal function, which may cause the measured GFR values be less reliable and thus the weaker correlation. ASL may be a better indicator for renal function.