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Abstract #2968

Relaxation Times as Biomarkers of Placental Tissue Morphology in Fetal Growth Restriction (FGR).

Caroline Wright1, David M. Morris2,3, Philip N. Baker1,4, Ian P. Crocker1, Penny A. Gowland5, Geoff Parker2,3, Colin P. Sibley1

1Maternal & Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom; 2Imaging Science & Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 3Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom; 4Faculty of Medicine & Dentistry, Univerity of Alberta, Alberta, Canada; 5Sir Peter Mansfield Magnetic Resonance Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Fetal growth restriction (FGR) is a serious complication of pregnancy associated with morphological changes within the placental tissue. MRI may be useful in non-invasive placental assessment by analysis of relaxation times, T1 and T2. We investigated placental relaxation times in utero at 1.5 T and the relationship with morphology in 30 normal and 10 FGR pregnancies. A significant correlation was seen between relaxation times and gestational age and between T2 and the placental fibrin content. 4 of 10 T2 values for FGR pregnancies lay below the 95th confidence band; interestingly these pregnancies had the most severe forms of FGR.