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Abstract #3005

Determination of ATP Synthesis Exchange Rates in Human Liver & Skeletal Muscle using 31P Magnetization Transfer

Tania Buehler1, Andreas Boss1, Roland Kreis1, Chris Boesch1

1Dept. of Clinical Research, University of Bern, Bern, Switzerland

The metabolic syndrome, which includes insulin resistance (IR), is a risk factor for cardiovascular diseases with epidemic dimensions. It is hypothesized that impaired mitochondrial activity could be a cause of IR. ATP synthesis exchange rates determined by 31P MRS allow a non-invasive estimation of mitochondrial activity. Several human studies exist for skeletal muscle, but only one for liver. Two methods (31P saturation (ST) and inversion transfer (IT)) have been implemented in combination with volume selection based on saturation bands. In this study the two methods for a determination of ATP synthesis exchange rates are compared in skeletal muscle and liver.