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Abstract #3007

Influence of Type 2 Diabetes on Intramyocellular Lipids Among Patients with Chronic Kidney Disease

Jimin Ren1, Manisha Shah2, Maram Museitif2, Lynne Roetzer2, A. Dean Sherry1,3, Craig R. Malloy1,4, Devasmita Choudhury2

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2VA North Texas Health Care System; 3Department of Chemistry, University of Texas at Dallas, Richardson, TX; 4VA North Texas Health Care System

Chronic kidney disease (CKD) and type 2 diabetes (T2D) are both highly prevalent and complex disorders. While T2D may cause CKD; CKD also independently causes insulin resistance. Increased intramyocellular lipids (IMCL) have been associated with insulin resistance and diabetes but the role of the compartmental distribution of lipids in normal physiology and disease is still debated. This study was designed to test the hypothesis that patients with T2D and CKD have higher levels of IMCL compared to patients with CKD but without overt T2D. Surprisingly, the results showed that IMCL was not significantly different in diabetic vs. nondiabetic CKD patients.