Tomoko Hyodo1,2, Masahiro Okada1, Yuki Kagawa1, Sachiyo Kogita3, Seishi Kumano1, Izumi Imaoka1, Masatoshi Hori4, Kazunari Ishii1, Yasuharu Imai3, Teruhito Mochizuki2, Masatoshi Kudo5, Takamichi Murakami1
1Radiology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan; 2Diagnostic & Therapeutic Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan; 3Gastroenterology, Ikeda Municipal Hospital, Ikeda, Osaka, Japan; 4Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 5Gastroenterology & Hepatology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan
To clarify the signiﬁcance of hypovascular nodules presented with hypointensity on hepatobiliary phase of Gd-EOB-DTPA enhanced MRI in screening for hepatocellular carcinoma (HCC) in the cirrhotic liver, 122 hypovascular hepatic nodules with hypointensity on hepatobiliary phase in 54 patients were reviewed. The incidence rate of developing hypervascular HCC from such nodules was 32%. Patients with higher growth rate (GR) may have potential arterial hypervascularization, and GR of >2.8x10-3 (tumor volume doubling time of < 355 days) may justifiy follow-up at short intervals.