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Abstract #3080

Feasibility of using MR Spectroscopy without Water-Fat Suppression to Monitor Tumor Response to Chemotherapy

Hyeon-Man Baek1, Jeon-Hor Chen2, Orhan Nalcioglu2, Min-Ying Su2

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Tu & Yuen Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States

The aim of our study was to determine the feasibility of using quantitative 1H-MRS without water-fat suppression to monitor tumor response to neoadjuvant chemotherapy. Our study showed the reduction in tCho at the first and second follow-up was significantly higher compared with the reduction in the tumor size (mean percentage change -72.6% vs. -9.7%, p < 0.0001; -96.6% vs. -56.7%, p < 0.003). In addition, the reduction in H2O and H2O/CH3 were also significantly higher than the reduction in tumor size at FU-1 (-36.2% vs. -9.7%, p = 0.028; -43.2% vs. -9.7%, p = 0.033). Therefore, the present study demonstrates that in vivo quantitative 1H-MRS without waterfat suppression can be useful for the detection and therapy response monitoring of breast cancer.