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Abstract #3082

Correlation between Apparent Diffusion Coefficient & Molecular & Histological Prognostic Factors in Breast Cancer: Initial Observations in 53 Patients.

Giuseppe Petralia1, Luke Bonello2, Paul Summers1, Lorenzo Preda1, Roberto Di Filippi1, Moreno Pasin1, Marzia Locatelli3, Giuseppe Curigliano3, Massimo Bellomi1,2

1Radiology, European Institute of Oncology, Milan, Italy; 2School of Radiology, University of Milan, Milan, Italy; 3Medical Oncology, European Institute of Oncology, Milan, Italy

The clinical course of breast cancer (BCa) depends on several molecular and histological characteristics. The aim of this study was to correlate apparent diffusion coefficient (ADC) with molecular and histological prognostic factors of BCa. Fifty-three BCa patients underwent DW-MRI of the breast. ADC was lower for HER-2 than for triple receptor negative subtype, and for T3 than for T1 BCa (P=.055 and .03, respectively). There was a marginally significant correlation (Spearman r=-0.35, P<.05) between ADC and HER-2 expression. There was no correlation between ADC and variables examined, with possible exception for HER-2. T3 subgroup may bear a distinct ADC behaviour.