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Abstract #3095

Normal Variability in the Quantitative Assessment of Breast Tissue by MRI

Ania Szary1, Sheye Aliu1, Sachiko Suzuki1, Catherine Klifa1, Dorota Wisner1, Evelyn Proctor1, Bonnie Joe1, Nola Hylton1

1Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States

Knowledge of normal breast tissue MRI variability is essential to increase MRI specificity in breast cancer detection. This study prospectively investigates variability of quantitative breast MRI parameters in healthy volunteers while controlling for hormonal fluctuation to improve knowledge of normal breast tissue range. All breast parameters show no significant difference between right and left breasts and between visits. Breast volume demonstrates the least variability per subject and amongst all subjects between visits, apparent diffusion coefficient values demonstrate the highest variability, and percent enhancement (PE) and fibroglandular volume show mild variability. No correlation between fibroglandular volume and PE was seen.