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Abstract #3107

Prediction of Lymphoma Response to Chemotherapy: Evaluation of Pre-Treatment MR Derived ADC & PET Derived SUV as Prognostic Biomarkers

Shonit Punwani1, Paul Humphries1, Stuart Taylor1, Stephen Daw2, Ananth Shankar2, Alan Bainbridge3, Ziauddin Zia Saad4, Ashley Groves4, Steve Halligan

1Centre for Medical Imaging, University College London, London, United Kingdom; 2Paediatrics, University College London Hospital; 3Department of Medical Physics & Bioengineering, University College London; 4Institute of Nuclear Medicine, University College London

Chemotherapy effect has been related to initial tumour cellular density and metabolic activity. ADC is correlated with cellular density and PET SUV measurements to metabolic activity. This study investigates the relationship between pretreatment ADC / SUV values treatment response as determined by tumour volume reduction.