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Abstract #3113

The DCE-MRI ╬┤Ktrans Parameter has Diminished Sensitivity to AIF Variation

Emerson Hum1, Xin Li1, Luminita Tudorica2, Karen Oh2, Stephanie Hemmingson1, Mark Kettler2, John Grinstead3, Gerhard Laub4, Charles Springer1, Wei Huang1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States; 3Siemens Healthcare, Portland, OR, United States; 4Siemens Healthcare, San Francisco, CA, United States

Ktrans is defined as [Ktrans(SSM) - Ktrans(SM)], resulted from analyzing a DCE-MRI data set twice, once with the Standard Model (SM) and once with the Shutter-Speed Model (SSM). SM and SSM fittings of DCE-MRI data from 8 malignant and 16 benign breast lesions were conducted using population-averaged AIF and reference-region AIF methods. Both Ktrans(SM) and Ktrans(SSM) values of malignant and benign groups changed significantly with different AIF approaches, while Ktrans was essentially insensitive to AIF variation. Use of the Ktrans imaging biomarker would be beneficial for multi-site DCE-MRI studies of cancer detection and therapeutic monitoring.