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Abstract #3126

Correlation of Intravoxel Incoherent Motion with Dynamic Contrast Enhanced MRI Derived Parameters in Neck Nodal Metastases

Yonggang Lu1, Jacobus F. A. Jansen2, Hilda E. Stambuk1, Yousef Tehrani-Mazaheri1, Nancy Lee1, Jason A. Koutcher1, Amita Shukla-Dave1

1Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Maastricht University Medical Center, Maastricht,, Netherlands

In the present study, correlation of quantitative parameters derived from IVIM- and DCE- MRI techniques was performed in neck nodal metastases. The results showed that D* (pseudo-diffusion coefficient) is positively correlated to Ktrans (volume transfer constant), vp( blood plasma volume fraction) and ve (extravascular extracellular space volume fraction) are positively correlated to D* and ADC (apparent diffusion coefficient), respectively. These initial results show the feasibility of characterizing diffusion and perfusion parameters using IVIM- and DCE- MRI in neck nodal metastases. In future, these techniques may be useful in assessing early treatment response in head and neck cancer patients.