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Abstract #3135

Monitoring Treatment Response to Neoadjuvant Chemotherapy in Breast Cancer by 3D Proton Magnetic Resonance Spectroscopy Imaging

Bogumil-Krystian Debski1, Wolfgang Bogner1, Marek Chmelik1, Katja Pinker, Thomas Helbich, Siegfried Trattnig1, Stephan Gruber1

1MR Centre of Excellence, Dept. Radiology, Medical University of Vienna, Vienna, Austria

In this study we evaluate the capability of 3D-MRSI to monitor the treatment response of neoadjuvant chemotherapy in breast cancer. Eleven patients with histology proven breast cancer were measured before and after chemotherapy on a 3T scanner. Mean SNR-values of choline decreased by 94%, 84% and 21% for excellent, good and poor/non responder, respectively. Further, the number of voxels which contained choline decreased by 92%, 70% and 38% for excellent, good and poor/non responder, respectively. Therefore, the number of choline containing voxels could be an additional marker for treatment response. In conclusion 3D-MRSI can be applied for monitoring treatment response in a clinically feasible measurement time.