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Abstract #3139

DCE-MRI as a Prognostic Factor in Osteosarcoma

Junyu Guo1, John O. Glass1, Qing Ji1, Catherine A. Billups2, Najat C. Daw3, Wilburn E. Reddick1

1Translational Imaging Research, Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, United States; 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States; 3Division of Pediatrics, MD Anderson Cancer Center, Houston, TX, United States

We investigated the role of DCE-MRI in evaluating tumor histological response to preoperative chemotherapy and predicting overall and event-free survival (EFS) of pediatric patients with newly diagnosed nonmetastatic osteosarcoma in an international, multi-institutional trial. We found that DCE-MRI parameters Ktrans and vp at week 9 of neoadjuvant therapy could serve as surrogate biomarker for histological response. And DCE-MRI parameter δve, the difference of ve between outer and inner 50% of tumor at week 0, may be a true early prognostic factor for EFS and overall survival, which eventually could contribute to the development of risk-adapted therapy.