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Abstract #3155

Characterization of Brain Tumor Infiltration into Adjacent Brain Tissue in Experimental Models with Diffusion Tensor Imaging (DTI)

Silun Wang1, Jinyuan Zhou1,2

1Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We evaluated the growth properties of 9L, F98, and GBM22 glioma models using DTI. Results indicated that significantly higher diffusion anisotropy in the immediate peritumoral region of glioma reflected tumor compression, whereas tumor cell infiltration disrupted neurofibers and decreased diffusion anisotropy. Significantly decreased FA and increased λ (with similar λ//) may be regarded as useful imaging patterns to determine damaged NAWM adjacent to glioma.