Lindsey Alexandra Crowe1, Frank Tobalem1,
David Tchernin2, Benedicte M-A. Delattre1, Kerstin
Grosdemange1, Marije Koenders3, Wim B. van Den Berg3,
Jean-Paul Valle1
1Division of Radiology,
Geneva University Hospitals, University of Geneva, Faculty of Medicine,
Foundation for Medical Researchers, Geneva, Switzerland; 2Division
of Radiology, Geneva University Hospitals, Geneva, Switzerland; 3Department
of Rheumatology, Rheumatology Research & Advanced Therapeutics, Radboud
University Nijmegen Medical Center, Netherlands
In-vivo MR imaging of intra and extra-articular oedema by T2 STIR MRI enables serial assessment of the progression of an antigen-induced arthritis (AIA) model in rat. Images were scored for the stage of the disease by consent of 3 readers after blinding. All left control knees scored zero for oedema and bone erosion, unlike diseased right knees that showed a rapid peak in extra-articular oedema, followed by intra-articular oedema and finally bone erosion.
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