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Abstract #3192

Progression of an Antigen-Induced Arthritis Model in Rat Assessed by MRI

Lindsey Alexandra Crowe1, Frank Tobalem1, David Tchernin2, Benedicte M-A. Delattre1, Kerstin Grosdemange1, Marije Koenders3, Wim B. van Den Berg3, Jean-Paul Valle1

1Division of Radiology, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Foundation for Medical Researchers, Geneva, Switzerland; 2Division of Radiology, Geneva University Hospitals, Geneva, Switzerland; 3Department of Rheumatology, Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Center, Netherlands

In-vivo MR imaging of intra and extra-articular oedema by T2 STIR MRI enables serial assessment of the progression of an antigen-induced arthritis (AIA) model in rat. Images were scored for the stage of the disease by consent of 3 readers after blinding. All left control knees scored zero for oedema and bone erosion, unlike diseased right knees that showed a rapid peak in extra-articular oedema, followed by intra-articular oedema and finally bone erosion.